Theta-burst patterned TMS protocols deliver bursts of high frequency pulses (e.g., 50-Hz) embedded in a theta rhythm (e.g., 5-Hz), which mimic the endogenous hippocampal-cortical theta-nested gamma rhythm that have been linked to memory processes.

Our previous research indicates that theta-burst patterned TMS targeted the hippocampal network has more robust effects on hippocampal network functional connectivity (Hermiller et al., 2019; Hermiller et al., 2022) and memory-related hippocampal activity (Hermiller et al., 2020).

We are interested in using theta-burst TMS to target the hippocampal network and modulate hippocampal-dependent memory processes, in order to better understand the putative functional role of theta rhythms in human memory processes.